Resolving Resolvins
نویسندگان
چکیده
منابع مشابه
Resolvins
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators. Here, we report that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid (DHA) (C22:6) produce a novel family of bioactive 17R-hydroxy-containing...
متن کاملResolvins and inflammatory pain
Resolvins are a group of molecules derived from omega-3 fatty acids. They are part of a biochemical program that allows inflamed tissues to return to homeostasis once the need for the inflammatory response is over. Resolvins act in very low dose ranges in vitro and in vivo. New data suggest that they might have the potential to become very potent analgesic drugs in inflammatory pain.
متن کاملThe What, Where, and How of Resolvins
* Author for correspondence: Dr.Shivani Dwivedi M.D.S (Periodontics), Senior Lecturer, Peoples Dental College and Research Centre, E-7/20, Char imli, Bhopal(M.P). Tel.: +919926027068, Email: [email protected]. Abstract. Complete resolution of an acute inflammatory response and its return to homeostasis are essential for healthy tissue. Once thought to be a passive process, the resolution o...
متن کاملResolvins suppress tumor growth and enhance cancer therapy.
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthresho...
متن کاملResolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives
The efficacy of many of pain-relieving drugs is based on mechanisms by which the drugs interfere with the body's natural pain-mediating pathways. By contrast, although it is less popular, other drugs including opioids exert more powerful analgesic actions by augmenting endogenous inhibitory neural circuits for pain mediation. Recently, a novel endogenous pain-inhibitory principle was suggested ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2013
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2013.02.003